This publication explores the powerful work of 35 womxn driving systemic change in often-overlooked regions of the United States, such as Kansas, Missouri, Arkansas, and Michigan. These womxn are addressing critical issues like climate change, economic inequality, and health disparities in ways that challenge the conventional notion of where innovation happens. Operating in politically challenging and resource-constrained environments, they are transforming their communities through bold, grassroots efforts that often go unrecognized.